Laboratory of Computational Genomics

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ARTICLES
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ARTICLES

発表論文

ゲノム情報医科学研究室における研究成果の発表状況として原著論文を掲載しています。

細道教授の業績はこちら
2023
2022

2023年原著論文 (英文)

  1. Mizumaki H, Tran DC, Hosokawa K, Hosomichi K, Zaimoku Y, Takamatsu H, Yamazaki H, Ishiyama K, Yamazaki R, Fujiwara H, Tajima A, Nakao S. Minor GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells. Blood Cancer J. 2023 Nov 8;13(1):165. doi: 10.1038/s41408-023-00932-5.
  2. Cho J, Horikawa Y, Oiwa Y, Hosomichi K, Yabe D, Imai T. Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients. International Journal of Molecular Sciences. 2023 Oct 31; 24(21):15842. doi:10.3390/ijms242115842
  3. Hazawa M, Ikliptikawati DK, Iwashima Y, Lin DC, Jiang Y, Qiu Y, Makiyama K, Matsumoto K, Kobayashi A, Nishide G, Keesiang L, Yoshino H, Minamoto T, Suzuki T, Kobayashi I, Meguro-Horike M, Jiang YY, Nishiuchi T, Konno H, Koeffler HP, Hosomichi K, Tajima A, Horike SI, Wong RW. Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells. Cell Chem Biol. 2023 Oct 30:S2451-9456(23)00366-5. doi: 10.1016/j.chembiol.2023.10.005.
  4. Kurayoshi K, Takase Y, Ueno M, Ohta K, Fuse K, Ikeda S, Watanabe T, Nishida Y, Horike SI, Hosomichi K, Ishikawa Y, Tadokoro Y, Kobayashi M, Kasahara A, Jing Y, Shoulkamy MI, Meguro-Horike M, Kojima K, Kiyoi H, Sugiyama H, Nagase H, Tajima A, Hirao A. Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation. Cell Death Dis. 2023 Sep 29;14(9):642. doi: 10.1038/s41419-023-06168-2.
  5. Okuwaki S, Hosomichi K, Tajima A, Yamaguchi T. An Observational Study on Changes in the Oral and Gut Microbiota through Professional Mechanical Tooth Cleaning, including Tooth-Brushing Instructions in Patients with Multi-Bracket Appliances. Applied Sciences. 2023 Sep 29; 13(19), 10843. doi:10.3390/app131910843
  6. Muromachi K, Hosomichi K, Park H, Yamaguchi T, Tani-Ishii N. Identification of Candidate Genes of Familial Multiple Idiopathic Cervical Root Resorption. J Endod. 2023 Sep 22:S0099-2399(23)00609-X. doi: 10.1016/j.joen.2023.09.008.
  7. Imi T, Mizumaki H, Hosomichi K, Nannya Y, Zaimoku Y, Yoroidaka T, Katagiri T, Ishiyama K, Yamazaki H, Ogawa R, Kuroiwa M, Tajima A, Ogawa S, Nakao S. Familial immune-mediated aplastic anaemia in six different families. EJHaem. 2023 Jun 28;4(3):714-718. doi: 10.1002/jha2.722. eCollection 2023 Aug.
  8. Hattori T, Cherepanov SM, Sakaga R, Roboon J, Nguyen DT, Ishii H, Takarada-Iemata M, Nishiuchi T, Kannon T, Hosomichi K, Tajima A, Yamamoto Y, Okamoto H, Sugawara A, Higashida H, Hori O. Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory. EMBO J. 2023 Aug 1;42(15):e111247. doi: 10.15252/embj.2022111247
  9. Peñaloza D, Paredes D, Arias-Almeida B, Hosomichi K, Reyes C, Romero VI. Novel ribosomal protein L26 variant and modeling in a patient with Diamond-Blackfan anemia: Case report. Pediatr Blood Cancer. 2023 Apr 19:e30368. doi: 10.1002/pbc.30368.
  10. Cui S, Hayashi K, Kobayashi I, Hosomichi K, Nomura A, Teramoto R, Usuda K, Okada H, Deng Y, Kobayashi-Sun J, Nishikawa T, Furusho H, Saito T, Hirase H, Ohta K, Fujimoto M, Horita Y, Kusayama T, Tsuda T, Tada H, Kato T, Usui S, Sakata K, Fujino N, Tajima A, Yamagishi M, Takamura M. The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants. J Mol Cell Cardiol. 2023 Apr;177:50-61. doi: 10.1016/j.yjmcc.2023.03.001.
  11. Nayema Z, Sato T, Kannon T, Tsujiguchi H, Hosomichi K, Nakamura H, Tajima A. Genetic factors associated with serum amylase in a Japanese population: combined analysis of copy-number and single-nucleotide variants. J Hum Genet. 2023 May;68(5):313-319. doi: 10.1038/s10038-022-01111-3.
  12. Yamamoto R, Takeshita Y, Tsujiguchi H, Kannon T, Sato T, Hosomichi K, Suzuki K, Kita Y, Tanaka T, Goto H, Nakano Y, Yamashita T, Kaneko S, Tajima A, Nakamura H, Takamura T. Nutrigenetic Interaction Between Apolipoprotein C3 Polymorphism and Fat Intake in People with Nonalcoholic Fatty Liver Disease. Current Developments in Nutrition. 2023 Apr;7(4) 100051-100051. doi: 10.1016/j.cdnut.2023.100051.
  13. Gau M, Suga R, Hijikata A, Kashimada A, Takagi M, Nakagawa R, Takasawa K, Shirai T, Kashimada K, Morio T. A novel variant of NR5A1, p.R350W implicates potential interactions with unknown co-factors or ligands. Front Endocrinol (Lausanne). 2023 Jan 20;13:1033074. doi: 10.3389/fendo.2022.1033074.
  14. Hayashi T, Yano N, Kora K, Yokoyama A, Maizuru K, Kayaki T, Nishikawa K, Osawa M, Niwa A, Takenouchi T, Hijikata A, Shirai T, Suzuki H, Kosaki K, Saito MK, Takita J, Yoshida T. Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy. Hum Mol Genet. 2023 Jan 16:ddad008. doi: 10.1093/hmg/ddad008.

2022年原著論文 (英文)

  1. Calvache CA, Vásquez EC, Romero VI, Hosomichi K, Pozo JC. Novel SRY-box transcription factor 9 variant in campomelic dysplasia and the location of missense and nonsense variants along the protein domains: A case report. Front Pediatr. 2022 Nov 18;10:975947. doi: 10.3389/fped.2022.975947.
  2. Park H, Hosomichi K, Kim YI, Hikita Y, Tajima A, Yamaguchi T. Comprehensive genetic exploration of fused teeth by whole exome sequencing. Applied Sciences. 2022 Nov 22;12(23) 11899-11899. doi: 10.3390/app122311899
  3. Saito S, Hosomichi K, Yamanaka MP, Mizutani T, Takeshima SN, Aida Y. Visualization of clonal expansion after massive depletion of cells carrying the bovine leukemia virus (BLV) integration sites during the course of disease progression in a BLV naturally-infected cow: a case report. Retrovirology. 2022 Nov 3;19(1):24. doi: 10.1186/s12977-022-00609-0.
  4. Roboon J, Hattori T, Nguyen DT, Ishii H, Takarada-Iemata M, Kannon T, Hosomichi K, Maejima T, Saito K, Shinmyo Y, Mieda M, Tajima A, Kawasaki H, Hori O. Isolation of ferret astrocytes reveals their morphological, transcriptional, and functional differences from mouse astrocytes. Front Cell Neurosci. 2022 Oct 6;16:877131. doi: 10.3389/fncel.2022.877131.
  5. Revathidevi S, Hosomichi K, Natsume T, Nakaoka H, Fujito NT, Akatsuka H, Sato T, Munirajan AK, Inoue I. AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells. Int J Mol Sci. 2022 Sep 22;23(19):11124. doi: 10.3390/ijms231911124.
  6. Tsuboi H, Matsunaga M, Tsujiguchi H, Kannon T, Hosomichi K, Sato T, Tajima A, Yoshida N, Hara A, Nakamura H. Elevated ratio of serum anandamide to arachidonic acid intake in community-dwelling women with high depressive symptoms. Neuro Endocrinol Lett. 2022 Sep 16;43(3):145-153.
  7. Park H, Hosomichi K, Kim YI, Tajima A, Yamaguchi T. Exploring the Genetic Basis of Dens Evaginatus Using Whole-Exome Sequencing Applied Sciences. 2022 Sep 6;12(18) 8962-8962. doi: 10.3390/app12188962
  8. Yamamura Y, Sato Y, Takahashi K, Nguyen Canh H, Zihan L, Hosomichi K, Tajima A, Terada T, Nakanuma Y, Harada K. A case of hepatic small vessel neoplasm without previously reported hotspot mutation of alpha subfamily of G proteins. Human Pathology Reports. 2022 Sep; 29:300660-300660. doi: 10.1016/j.hpr.2022.300660
  9. Yamaguchi T, Hosomichi K, Shirota T, Miyamoto Y, Ono W, Ono N. Primary failure of tooth eruption: Etiology and management. Jpn Dent Sci Rev. 2022 Nov;58:258-267. doi: 10.1016/j.jdsr.2022.08.002.
  10. Goto RM, Warden CD, Shiina T, Hosomichi K, Zhang J, Kang TH, Wu X, Glass MC, Delany ME, Miller MM. The Gallus gallus RJF reference genome reveals an MHCY haplotype organized in gene blocks that contain 107 loci including 45 specialized, polymorphic MHC class I loci, 41 C-type lectin-like loci, and other loci amid hundreds of transposable elements. G3 (Bethesda). 2022 Nov 4;12(11):jkac218. doi: 10.1093/g3journal/jkac218.
  11. Kawashima S, Yuno A, Sano S, Nakamura A, Ishiwata K, Kawasaki T, Hosomichi K, Nakabayashi K, Akutsu H, Saitsu H, Fukami M, Usui T, Ogata T, Kagami M. Familial Pseudohypoparathyroidism Pham LT, Peng H, Ueno M, Kohno S, Kasada A, Hosomichi K, Sato T, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy MI, Xiao B, Worley PF, Takahashi C, Tajima A, Hirao A. Type IB Associated with an SVA Retrotransposon Insertion in the GNAS Locus. J Bone Miner Res. 2022 Oct;37(10):1850-1859. doi: 10.1002/jbmr.4652.
  12. Pham LT, Peng H, Ueno M, Kohno S, Kasada A, Hosomichi K, Sato T, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy MI, Xiao B, Worley PF, Takahashi C, Tajima A, Hirao A. RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia. Biochem Biophys Res Commun. 2022 Sep 17;621:74-79. doi: 10.1016/j.bbrc.2022.06.089. Epub 2022 Jun 30.
  13. Castillo MI, Freire E, Romero VI, Arias-Almeida B, Reyes C, Hosomichi K. Novel Variation in Acyl-CoA Synthetase Long Chain Family Member 6 (ACSL6) Results in Protein Structural Modification and Multiple Non-Related Neoplasia in a 46-Year-Old: Case Report. Front Oncol. 2022 Jun 2;12:899579. doi: 10.3389/fonc.2022.899579.
  14. Suzuki K, Tsujiguchi H, Hara A, Pham OK, Miyagi S, Nguyen TTT, Nakamura H, Suzuki F, Kasahara T, Shimizu Y, Yamada Y, Kambayashi Y, Tsuboi H, Sato T, Kannon T, Hosomichi K, Tajima A, Takamura T, Nakamura H. Association Between Serum 25-Hydroxyvitamin D Concentrations, CDX2 Polymorphism in Promoter Region of Vitamin D Receptor Gene, and Chronic Pain in Rural Japanese Residents. J Pain Res. 2022 May 23;15:1475-1485. doi: 10.2147/JPR.S356630.
  15. Yamanaka MP, Saito S, Hosomichi K, Aida Y. Comprehensive Comparison of Novel Bovine Leukemia Virus (BLV) Integration Sites between B-Cell Lymphoma Lines BLSC-KU1 and BLSC-KU17 Using the Viral DNA Capture High-Throughput Sequencing Method. Viruses. 2022 May 7;14(5):995. doi: 10.3390/v14050995.
  16. Pham KO, Hara A, Tsujiguchi H, Suzuki K, Suzuki F, Miyagi S, Kannon T, Sato T, Hosomichi K, Tsuboi H, Nguyen TTT, Shimizu Y, Kambayashi Y, Nakamura M, Takazawa C, Nakamura H, Hamagishi T, Shibata A, Konoshita T, Tajima A, Nakamura H. Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study. Nutrients. 2022 May 16;14(10):2082. doi: 10.3390/nu14102082.
  17. Yamanaka MP, Saito S, Hara Y, Matsuura R, Takeshima SN, Hosomichi K, Matsumoto Y, Furuta RA, Takei M, Aida Y. No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan. Retrovirology. 2022 May 18;19(1):7. doi: 10.1186/s12977-022-00592-6.
  18. Nanjo S, Wu W, Karachaliou N, Blakely CM, Suzuki J, Chou YT, Ali SM, Kerr DL, Olivas VR, Shue J, Rotow J, Mayekar MK, Haderk F, Chatterjee N, Urisman A, Yeo JC, Skanderup AJ, Tan AC, Tam WL, Arrieta O, Hosomichi K, Nishiyama A, Yano S, Kirichok Y, Tan DS, Rosell R, Okimoto RA, Bivona TG. Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. J Clin Invest. 2022 Jul 1;132(13):e145099. doi: 10.1172/JCI145099.
  19. Sakai K, Ishida C, Hayashi K, Tsuji N, Kannon T, Hosomichi K, Takei N, Kakita A, Tajima A, Yamada M. Familial idiopathic basal ganglia calcification with a heterozygous missense variant (c.902C>T/p.P307L) in SLC20A2 showing widespread cerebrovascular lesions. Neuropathology. 2022 Apr;42(2):126-133. doi: 10.1111/neup.12781.
  20. Takahashi M, Hosomichi K, Nakaoka H, Sakata H, Uesato N, Murakami K, Kano M, Toyozumi T, Matsumoto Y, Isozaki T, Sekino N, Otsuka R, Inoue I, Matsubara H. Biased expression of mutant alleles in cancer-related genes in esophageal squamous cell carcinoma. Esophagus. 2022 Apr;19(2):294-302. doi: 10.1007/s10388-021-00900-7.
  21. Nomura N, Iizuka K, Goshima E, Hosomichi K, Tajima A, Kubota S, Liu Y, Takao K, Kato T, Mizuno M, Hirota T, Suwa T, Horikawa Y, Yabe D. Glucokinase-maturity onset diabetes mellitus in the young suggested by factory-calibrated glucose monitoring data: a case report. Endocr J. 2022 Apr 28;69(4):473-477. doi: 10.1507/endocrj.EJ21-0526.
  22. Hara T, Yamada I, Ohashi T, Tamura M, Hijikata A, Watanabe T, Gao M, Ito K, Kawamata S, Azuma S, Yoshigai E, Sumiyoshi Y, Yasuhiro N, Ohara O, Santos HGD, Fukada T. Role of Scl39a13/ZIP13 in cardiovascular homeostasis. PLoS One. 2022 Oct 21;17(10):e0276452. doi: 10.1371/journal.pone.0276452.
  23. Satow R, Suzuki Y, Asada S, Ota S, Idogawa M, Kubota S, Ikeo N, Yoneda A, Fukami K. Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells. iScience. 2022 Nov 4;25(12):105501. doi: 10.1016/j.isci.2022.105501.
  24. Satow R, Watanabe T, Nomura M, Inagaki S, Yoneda A, Fukami K. Patulin and LL-Z1640-2 induce apoptosis of cancer cells by decreasing endogenous protein levels of Zic family member 5. J Cell Mol Med. 2022 Nov;26(22):5680-5689. doi: 10.1111/jcmm.17598.
  25. Satow R, Aiga Y, Watanabe T, Ishizuka N, Yoneda A, Fukami K. Zic family member 5 promotes survival in human pancreatic cancer and cholangiocarcinoma cells. Biochem Biophys Rep. 2022 Jun 2;31:101289. doi: 10.1016/j.bbrep.2022.101289.